Interaction between SNPs in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk
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چکیده
Affiliations of authors: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK (MLC, FRG, MPR), Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (HOA, HG, FW), Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA (HOA), Dana-Farber/Harvard Cancer Center, Boston, MA, USA (HOA), Joint Senior Authors (FRG, MPR) Correspondence to: Professor Margaret Rayman, Nutritional Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK Tel: +44 (0)1483 686447 Fax +44 (0)1483 686401
منابع مشابه
Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk.
Selenium may affect prostate cancer risk via its plasma carrier selenoprotein P which shows dramatically reduced expression in prostate cancer tumors and cell lines. The selenoprotein P (SEPP1) Ala234 single nucleotide polymorphism (SNP) allele is associated with lower plasma selenoprotein P in men, reducing the concentration/activity of other antioxidant selenoproteins. Selenium status also mo...
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BACKGROUND Genetic variants in antioxidant pathways might decrease the efficacy of radiation therapy (RT) by suppressing the generation of reactive oxygen species. We studied the association between single nucleotide polymorphisms (SNPs) in the antioxidant gene superoxide dismutase-2 (SOD2) and cancer-specific outcomes after RT. PATIENTS AND METHODS Among 816 prostate cancer patients who rece...
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Oxidative stress may enhance prostatic carcinogenesis. A polymorphism [valine (V) ! alanine (A)] of manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, has been recently associated with prostate cancer. We examined the relationship between prostate cancer and the MnSOD polymorphism and its interactions with baseline plasma antioxidant levels (selenium, lycope...
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Increased dietary intake of Selenium (Se) has been suggested to lower prostate cancer mortality, but supplementation trials have produced conflicting results. Se is incorporated into 25 selenoproteins. The aim of this work was to assess whether risk of prostate cancer is affected by genetic variants in genes coding for selenoproteins, either alone or in combination with Se status. 248 cases and...
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تاریخ انتشار 2012